D-manno-2-octulosonic acid derivatives, pharmaceutical compositi

Details D-manno-2-octulosonic acid derivatives, pharmaceutical compositi D-manno-2-octulosonic acid derivatives, pharmaceutical compositi

1985-08-19

1986-09-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 11, 536 187, 536 53, 536 55, A61K 3170, C07H 308

Patent

active

046135898

ABSTRACT:
Derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.

REFERENCES:
patent: 3719659 (1973-03-01), Magerlein
patent: 4454123 (1984-06-01), Noyori et al.
Charon et al., "J.C.S." Perkin I, pp. 1971-1977, 1980.
Collins et al., "J.C.S. Chem. Comm.", pp. 1139-1140, 1981.
Strain et al., "J. Bio. Chem.", vol. 258, No. 22, pp. 13466-13477, 1983.
Strain et al., "J. Bio. Chem.", vol. 258, No. 5, pp. 2906-2910, 1983.
Bigham et al., "J. Med. Chem.", vol. 27, pp. 717-726, 1984.
Molin et al., "Tetrahedron Letters", vol. 26, No. 5, pp. 677-680, 1985.

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