D,L-2-Amino-4-(2-aminoethoxy)-trans-but-3-enoic acid derivatives

Details D,L-2-Amino-4-(2-aminoethoxy)-trans-but-3-enoic acid derivatives D,L-2-Amino-4-(2-aminoethoxy)-trans-but-3-enoic acid derivatives

1977-08-15

1980-12-09

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560159, 560160, 560169, 560170, 562448, 562564, 260326N, 260456A, C07C10128

Patent

active

042386225

ABSTRACT:
The amino acid 2-amino-4-(2-aminoethoxy)-trans-but-3-enoic acid can be conveniently prepared via novel intermediates from a 2,2'-disubstituted diethyl ether and a dialkyl N-protected amidomalonate starting material using a multi-step process. Preferred starting materials are bis-2-chloroethyl ether and diethyl acetamidomalonate. The process, in a preferred embodiment, proceeds through the key intermediate ethyl-2-acetamido-4-[2-(2-phthalimido)ethoxy]-but-2-enoate.

REFERENCES:
patent: 3751459 (1973-08-01), Berger et al.
patent: 3865694 (1975-02-01), Berger et al.
patent: 3887615 (1975-06-01), Keith et al.
patent: 3991077 (1976-11-01), Uzuki et al.
patent: 4014898 (1977-03-01), Keith et al.
patent: 4115105 (1978-09-01), Scannell

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