D-isomers of antimicrobial peptide

Details D-isomers of antimicrobial peptide D-isomers of antimicrobial peptide

2007-09-18

2007-09-18

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C514S014800

Reexamination Certificate

active

11213245

ABSTRACT:
This invention provides D-isomers of MUC7-12-mer peptide of human saliva MUC7. The isomers have antimicrobial activity comparable to that of the L-isomers and are resistant to proteolysis. These peptides can be used as antifungal and antimicrobial agents.

REFERENCES:
patent: 6790833 (2004-09-01), Bobek
Gururaja, et al., Candidacidal Activity Prompted by N-Terminus Histatin-like Domain of Human Salivary Mucin (MUC-7), BBA 1431 (1999) pp. 107-119.
Satyanarayana, et al., Divergent Solid-phase Synthesis and Candidacidal Activity of MUC7 D1, a 51-Residue Histidine-rich N-terminal Domain of Human Salivary Mucin (MUC7), J. Peptide Res., 2000, 56, pp. 275-282.

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