D-homopregnanes

Details D-homopregnanes D-homopregnanes

1978-04-20

1978-12-26

Schwartz, Gerald A.

Chemistry of carbon compounds

Dipeptides, e.g., aspartame, anserine, carnosine, etc.

560 61, 560 62, 560 64, 560 65, 560 43, 560107, 560194, 560257, 260457, 260586E, 424214, 424266, 424303, 424308, 424309, 424310, 424313, 424331, 546263, 546285, C07F 909, C07C 4944

Patent

active

041316550

ABSTRACT:
D-homopregnanes of the formula ##STR1## wherein R.sup.6 is hydrogen, chloro, fluoro or methyl; X is .beta.-hydroxymethylene or carbonyl; R.sup.17a is hydroxy, lower alkanoyloxy or aroyloxy; R.sup.21 is hydrogen, chloro, fluoro, hydroxy, lower alkanoyloxy, aroyloxy, sulfate or phosphate; and the dotted line in the 1,2-position of the A-ring denotes an additional carbon-carbon bond
And pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them as the active ingredient are disclosed. The D-homopregnanes of the present invention exhibit hormonal activity and are useful for the treatment of inflammation.

REFERENCES:
patent: 3939193 (1976-02-01), Alig et al.
patent: 4036874 (1977-07-01), Alig et al.
patent: 4057561 (1977-11-01), Furst et al.
Heller et al., Steroids 7, 381 (1966).

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