D-Homo oxasteroids

Details D-Homo oxasteroids D-Homo oxasteroids

1977-07-20

1978-09-26

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424283, C07D31102, A61K 3135

Patent

active

041169786

ABSTRACT:
Steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R.sub.1 is hydrogen, acyloxy, halogen, or hydroxy; R.sub.2 is hydrogen or alkyl; R.sub.3 is alkyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; R.sub.6 is hydrogen, fluorine or methyl; and R.sub.7 is hydrogen, chlorine or bromine; can be used as antiinflammatory agents.

REFERENCES:
patent: 2832772 (1958-04-01), Farrar et al.
patent: 3294819 (1966-12-01), Krakower et al.
patent: 3467677 (1969-09-01), Gardner
Iriarte et al., J.C.S. Chem. Comm., 1110 (1972).
Kuo et al., J. Org. Chem., 28, 1619 (1963).

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