Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-12-17
1977-11-01
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260586C, 260349, 260455R, 260454, 260464, 260573, 544 58, C01B 3324, C07J 6300
Patent
active
040566331
ABSTRACT:
D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido;
R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methyl
R.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino;
R.sub.6 is methyl or ethyl;
The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration;
And acid addition salts thereof, possess narcotic-anesthetic activity.
REFERENCES:
patent: 3876705 (1975-04-01), Valenta
Engelfried Otto
Kerb Ulrich
Kieslich Klaus
Wachtel Helmut
Wiechert Rudolf
Jiles Henry R.
Owens Cary
Schering Aktiengesellschaft
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