D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

Details D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

1992-08-05

1993-10-12

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

A61K 31395, C07D49116

Patent

active

052527328

ABSTRACT:
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

REFERENCES:
patent: 5064835 (1991-11-01), Bochis et al.
patent: 5110811 (1992-05-01), Okuhara et al.
patent: 5118677 (1992-06-01), Caufield
patent: 5143918 (1992-09-01), Bochis et al.
Barton, et al., J. Chem. Soc. Chem. Commun., 65-66 (1986) (I).
Barton, et al., Tetrahedron Lett., 27(31), 3615-3618 (1986) (I).

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