Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-03-19
1996-11-05
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514561, 514563, 562564, 562567, A01N 3718, A01N 3730
Patent
active
055718396
ABSTRACT:
Beta-hydroxamate D-aspartic acid as a medicine, in particular for treating infectious diseases caused by retroviruses, especially those that cause AIDS, as well as for treating tumors.
REFERENCES:
Abstract to EP 250335 23 Dec. 1987 Dore et al.
Gardner, "Amino Acid Analysis in the Study of Protein Digestion and Absoron", Chpt. 10, Amino Acid Analysis in the Study of Physiological Processes, Part 2, pp. 158-187, 1985.
Geran et al., Protocols for Screening Chemical Agents and Natural Products Against Animal Tumors and Other Biological Systems, 1973 Mar., pp. 1, 47-56, 57.
DeVita et al., "Cancer Drug Development" Cancer Principles and Practice of Oncology 2.sup.nd Ed., pp. 271-274, 1985.
Norton et al., ".beta.-Aspartylhydroxamic Acid: Its Action as a Feedback Inhibitor and a Repressor of Asparagine Synthetase in Lactobacillus arabinossus", Archives of Biochemistry and Biophysics 129, pp. 560-566, 1969.
Uren et al., "Effects of Asparagine Synthetase Inhibitors on Asparaginase Resistant Tumors", Biochem. Pharmacology, vol. 26, 15, pp. 1405-1410, 1977.
Translation to EP, A, 0250335, having a publication date of 23 Dec. 1987.
Cancer Chemotherapy Reports; Sep. 1972; vol. 3, No. 2; Protocols 4, 11 and 12.
Grange Jacques
Hamedi Sangsari Farid
Thomasset Nicole
Vila Jorge
Geist Gary
Institut National de la Sante et de la Recherche Medicale (INSER
Jones Dwayne C.
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