D-arabinose-1,5-diphosphate salts and methods for the treatment

Details D-arabinose-1,5-diphosphate salts and methods for the treatment D-arabinose-1,5-diphosphate salts and methods for the treatment

1985-12-12

1988-05-17

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514866, 536 41, A61K 31665, C07H 1104, C07H 1300

Patent

active

047451858

ABSTRACT:
Novel D-arabinose-1,5-diphosphate salts of the formula (I): ##STR1## wherein n is from about 3 to 4 and M.sup.+ is a cation as well as racemic and isomeric mixtures of the so-defined and forms of formula (I) are useful as hypoglycemic agents for the treatment of diabetes, e.g., in man.

REFERENCES:
S. J. Pilkis, et al., Academic Press, Inc., vol. 89, pp. 101-107 (1982).
G. M. Tener, et al., Journal of the American Chemical Society, vol. 80, pp. 1999-2004 (1958).
Gene F. Tutwiler, Biochemical Medicine, vol. 22, pp. 204-213, Academic Press, Inc. (1979).
Motoyuki Yajima and Michio Ui, American Journal of Physiology, vol. 227, pp. 1-8, (1974), Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University.
Pilkis et al., The Journal of Biological Chemistry, vol. 256, No. 7, pp. 3171-3174, (1981), Departments of Physiology and Molecular Biology, Vanderbilt University.
Benkovic et al., Biochemistry, vol. 10, No. 26, pp. 4881-4887, (1971), Department of Chemistry, The Pennsylvania State University.
Benkovic et al., " . . . Fructose-1,6-Diphosphatase Inhibition by Structural Analogs of Fructose 1,6-Diphosphate", Chem. Abs. 76:43379s (1971).
Stryer, Biochemistry (2d Ed.), p. 543 (FIG. 23-8) (1981).

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