D-aminoacylase and gene encoding the same

Details D-aminoacylase and gene encoding the same D-aminoacylase and gene encoding the same

2005-05-03

2005-05-03

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S183000, C435S195000, C530S350000, C536S023100, C536S023200

Reexamination Certificate

active

06887697

ABSTRACT:
The present invention provides the D-aminoacylase-encoding gene derived fromHypomyces mycophilus, a filamentous fungus, the polypeptide encoded by the gene, and the homologues thereof. The D-aminoacylase of the present invention is capable of producing D-tryptophan from N-acetyl-D-tryptophan. D-tryptophan is useful as a medicinal raw material or the like.

REFERENCES:
patent: 0677585 (1995-10-01), None
patent: 0896057 (1999-02-01), None
patent: 0976828 (2000-02-01), None
patent: WO 0023598 (2000-04-01), None
Grifantini et al. Accession AAR82837. Mar. 13, 1996 (Alignment SEQ ID No.: 2).*
Broun et al. Science. Nov. 13, 1998;282(5392):1315-7.*
Makiko Sugie et al., “Optical Resolution of DL-Amino Acids with D-Aminoacylase ofStreptomyces”, Agric. Biol. Chem., 44(5), 1089-1095, 1980.
Kubo et al., Deacetylation of PS-5, A New β-Lactam compound III. Enzymological Characterization of L-Amino Acid Acylase and D-Amino Acid Acylase from Pseudomonas SP. 1158, J. Antibiot., 33:556-565, 1980.
Moriguchi et al., “Purification and Characterization of Novel N-Acyl-D-asparate Amidohydrolase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6”, Biosci. Biotech. Biochem., 57:1145-1148, 1993.
Sakai et al., “Purification and characterization of N-acyl-D-glutamate deacylase from Alcaligenes xylosoxydans A-6”, FEBS, 289:44-46, 1991.
Sakai et al., “Purification and Properties fo D-Aminoacylase from Alcaligenes denitrificans subsp. xylosoxydans MI-4”, J. Ferment. Bioeng. 71:79-82, 1991.
Sugie et al., “Purification and Properties of D-Aminoacylase of Streptomyces olivaceus”, Agric. Biol. Chem. 42:107-113, 1978.
Wakayama et al., “Primary Structure of N-Acyl-D-Glutamate Amidohydrolase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6”, J. Biochem., 118:204-209, 1995.
Wakayama et al., “Cloning and Sequencing of a Gene Encoding D-Aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6 and Expression of the Gene inEscherichia coli”, Biosci. Biotech. Biochem., 59:2115-2119, 1995.

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