D-amino acid analogs of beta-endorphin

Details D-amino acid analogs of beta-endorphin D-amino acid analogs of beta-endorphin

1977-03-11

1982-03-02

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043177700

ABSTRACT:
D-amino acid analogs in positions 1,2,4 and 5 of .beta.-endorphin are synthesized by solid phase techniques. These compounds and, particularly [D-Ala.sup.2 ]-.beta.-endorphin, exhibit opiate agonist and analgesic activity.

REFERENCES:
patent: 4038222 (1977-07-01), Li
G. Ungar, et al., Opiates and Endogenous Opioids Peptides 1976 pp. 121-128.
D. H. Coy, et al., Biochem. and Biophys. Res. Commun. 73, 1976, pp. 632-638.

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