D-Allose derivative and preparation method therefor

Details D-Allose derivative and preparation method therefor D-Allose derivative and preparation method therefor

1981-03-20

1982-09-14

Siegel, Alan

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 53, A61K 3170, C08B 3700

Patent

active

043495460

ABSTRACT:
3-[3-(2-Haloethyl)-3-nitrosoureido]-3-deoxy-D-alloses are new, antitumor compounds having a far lower myelotoxicity as compared with conventional antitumor agents. They are obtained by treating 3-[3-(2-haloethyl)ureido]-3-deoxy-1,2,5,6,-di-O-isopropylidene-.alpha.-D-a llofuranoses with a nitrosating agent and then hydrolyzing the protective group in the presence of an acid.

REFERENCES:
patent: 4156777 (1979-05-01), Kimura
patent: 4211866 (1980-07-01), Matsumura
patent: 4241052 (1980-12-01), Tsujihara

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