(D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzo pyran-4,4'-

Details (D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzo pyran-4,4'- (D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzo pyran-4,4'-

1989-03-31

1991-07-30

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514389, 514390, 546256, 546269, 548309, A61K 31415, C07D491107

Patent

active

050360809

ABSTRACT:
Hydantoin derivatives of the formula ##STR1## wherein Ra and Rb are same or different, each being hydrogen atom, alkanoyl, substituted or none-substituted aroyl, heteroaroyl, alkoxycarbonyl, substituted or none-substituted aralkoxycarbonyl, aryloxycarbonyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, substituted or none-substituted N-aralkylcarbamoyl, alkoxyalkyl, 1-(acyloxy)-alkyl, alkylmercapto, substituted or none-substituted arylmercapto, alkylsulfinyl, substituted or none-substituted arylsulfinyl, alkylsulfonyl or substituted or none-substituted arylsulfonyl, but both of Ra and Rb do not concurrently mean hydrogen atom,
a process for the preparation of the derivatives, and use thereof as an agent for preventing and curing chronic complications due to diabetes.

REFERENCES:
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patent: 4650798 (1987-03-01), Minami et al.
patent: 4780472 (1988-10-01), Ueda et al.
March, J., Advanced Organic Chemistry, McGraw Hill. New York, 1968, pp. 672-673.
J. Kinoshita et al., Jap. J. Opthalmol. vol. 20, pp. 339-410, 1976.
K. Gabbay, Int. Congr. Ser. Excerpta Med., vol. 403, p. 594, 1977.
M. Peterson et al., Metabolism, vol, 28, p. 456, 1979.

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