Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-10-02
2007-10-02
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S388900, C530S389800, C530S405000, C530S406000, C558S199000
Reexamination Certificate
active
11185361
ABSTRACT:
Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide.
REFERENCES:
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G. Zon et al, (1982) HCAPLUS abstract accession No. 1982: 416494. O-Methylhydroxylamine as a new trapping reagent for quantitative studies of 4-hydroxycyclophosphamide and aldophosphamide.
S. Ludeman et al, (1985) HCAPLUS abstract accession No. 1995: 448403. Oxime Derivatives of the Intermediary Oncostatic Metabolites of Cyclophosphamide and Ifosfamide: Synthesis & Deuterium Labeling for Applications to Metabolite Quantification.
The International Search Report and Written Opinion of the International Searching Authority by the International Searching Authority, issued on Mar. 7, 2007, in the PCT application No. PCT/US05/25483.
Chen et al., Nonlinear Pharmacokinetics of Cyclophosphamide and 4-Hydroxycyclophosphamide/Aldophosphamide in Patients with Metastatic Breast Cancer Receiving High-dose Chemotherapy Followed by Autologous Bone Marrow Transplantation, 1997, Drug Mutabolism & Disposition, vol. 25, No. 5, pp. 544-551.
Drug Metabolism and Dispositon. 1997, vol. 25, No. 5, pp. 544-551.
Courtney Jodi Blake
Salamone Salvatore J.
Stocker Dennis
Haq Shafiqul
Le Long V.
Saladax Biomedical Inc.
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