Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-01-23
1993-11-09
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514167, 514168, 514458, 514560, 514558, 514573, 514972, A61K 3722, A61K 3159, A61K 31595, A61K 31355
Patent
active
052600670
ABSTRACT:
A series of cytotropic heterogeneous molecular lipids (CHML) and the method of preparation thereof are disclosed in the invention. CHML provided by this invention is in molecular type, it is an activated molecular carrier of functions with orientionally penetrating into membranes or walls of the cells. It possesses the active site for binding anti-carcinogenic drugs which is water soluble, lipid soluble or gas soluble and possesses the activated portion for binding structure of membrane of cancer cells also.
CHML can synergetically injure the carcinoma cells and varius verus, at the same time it can enhance the immunity of the body. These are ascertained by the animal tests and in vitro tests.
CHML in this invention can kill the sarcoma cell S-180 within 50 min. and the cells of human squamous cell carcinoma of esophagus within 40 min.
The rate of DNA and RNA depolymerizations in cancer cells and mortality of cancer cells are attained to 100%. These are evidenced in the vitro test also.
REFERENCES:
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Gu Xuequi, et al.: Introduction of Polyphase Liposome A Promosing Carrier for Chemotherapeutic Agents, Research Bulletins and Abstract for FIrst Beijing Int'l Symposium on Cancer Chemotherapy, Sep. 7-9, 1986, Beijing, China.
Liu Guo-jie. Yao Ji Xue (pharmaceutics). Second edition. People's publishing house. Beijing. 1985; pp. 992-993.
Gu-Xue-qin. Yao Wu Zhi Ji Xi Ji Xung Xuan Bian (selected edition of new types of pharmaceutics). People's health publishing house, Beijing. 1984 p. 123.
Ren Min Zheng Xie Bao (newspaper of People's political consultative conference) 1984, Nov. 12.
Mar X, J. L. Liposomes: research applications grow Science 1987; 199:1056.
Gregoriadis, G. The carrier potential of liposomes in biology and medicine N. Engl. J. Med. 1976; 295:704,765. Parts I and II.
C. R. Alving. Lipsome Techniques in Cell Biology. Nature 1987; vol. 330, 1189.
Waddell Frederick E.
Weddington K.
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