Cytotoxicity assays in cell culturing devices

Details Cytotoxicity assays in cell culturing devices Cytotoxicity assays in cell culturing devices

1983-02-04

1985-12-17

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 3, 435 4, 435240, 435241, 435284, 435287, 435291, 435808, 435810, 435811, 436 4, 436 34, 436 63, 436 68, 436178, 422 48, 422 61, 422 68, C12Q 129, C12Q 300, C12N 500, C12N 502, C12M 300, C12M 100, C12M 134, G01N 3354

Patent

active

045592993

ABSTRACT:
Methods and devices for assaying the sensitivity of of biopsied cells to therapeutic agents are disclosed. Cells are cultured in artificial organs and then contacted with a fluorogenic substrate such that living cells accumulate a characteristic amount of fluorescence. The agent is then introduced into the organ and changes in the fluorescence released by the cells serve as an indicator of the sensitivity of the cells to the agent.

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