Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1985-06-28
1988-11-08
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435212, 435213, C12N 916, C12N 948, C12N 976
Patent
active
047834102
ABSTRACT:
A novel serine esterase produced by cytotoxic T lymphocytes is insolated and characterized. The protein appears to be membrane bound and has a reduced apparent molecular weight of about 28,000 daltons. Inhibition of the esterase correlates with inhibition of the cells' cytolytic activity. The serine esterase is useful in making antibody and as a target for the inhibition of cytolytic activity by T-lymphocytes, both in vivo and in vitro.
REFERENCES:
Hatcher, V. B., et al. (1978) J. Immunol. 120, 665-670.
"Effects of N"-Tosyl-1-Lysyl-Chloromethylketone on the Activity of Cytotoxic T Lymphocytes.sup.1 ", by Tse Wen Chang and Herman N. Eisen, J. Immunol., 124, 1028-1033, (1980).
"The Mechanism of Cell-Mediated Cytotoxicity", by Doug Redelman and Dorothy Hudig, J. Immunol. 124, 870-878 (1980).
"Inhibition of Human Natural Cytotoxicity by Macromolecular Antiproteases'", by D. Hudig et al., J. Immunol. 126, 1569-1574 (1981).
"Studies on the Mechanism of NK Cell Lysis'", by P-C. Quan et al., J. Immunol. 128, 1786-1791 (1982).
"The Requirement for Proteinase Activity for Human Lymphocyte-Mediated Natural Cytotoxicity (NK) Evidence that the Proteinase is Serine Dependent and has Aromatic Amino Acid Specificity of Cleavage.sup.1 ", by D. Hudig et al. J. Immunol 133 2647-2654 (1984).
"The Site of Action of N-.alpha.-Tosyl-1-Lysyl-Chloromethyl-Ketone (TLCK) on Cloned Cytotoxic T. Lymphocytes'", by M. S. Pasternack et al., J. Immunol. 131, 2477-2483 (1983).
"Cyclical Changes in Susceptibility of a Myeloma Tumor (LPC-1) /to Immune Destruction", by E. Celis et al. J. Immunol. 122, 954-958 (1979).
Eisen Herman N.
Pasternack Mark S.
Massachusetts Institute of Technology
Patterson Jr. Charles L.
Wiseman Thomas G.
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