Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines

Details Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines

1994-05-31

1999-02-16

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

530350, 4241881, 4241841, 4242041, A61K 3921, A61K 3900, A61K 3938, C07K 100

Patent

active

058717463

ABSTRACT:
Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one antigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups.
Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses. DA.

REFERENCES:
Martinon, et al, 1992, "Immunization of mice with lipopeptides . . . " J. munol. 145 (10):3416-22.
Bahraoui, et al, 1992, "Immunogenicity of the human . . . " AIDS Res Hum. Retro. 6(9): 1087-1098.
Haynes, 1993, "Scientific and Social Issues . . . " Science 260: 1279-1286.
Butini, et al, 1994, "Comparative analysis of HIV-Specific . . . " J. Cell. Biochem. Suppl. 18B, Abstract J306.
Fox, 1994, "No Winners Against AIDS", Biotechnology 12;128.

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