Cytotoxic T lymphocyte-inducing lipopeptides and methods of use

Details Cytotoxic T lymphocyte-inducing lipopeptides and methods of use Cytotoxic T lymphocyte-inducing lipopeptides and methods of use

1995-06-07

1999-11-30

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241881, 4241841, 4247041, 530350, A61K 3921, A61K 3912, A61K 3938, C07K 1700

Patent

active

059938234

ABSTRACT:
Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide fragment having approximately between 10 and 40 amino acids and comprising at least one antigenic determinant and also comprising one or more chains derived from fatty acids and one or more modified steroid groups useful for immunizing a human or animal body against pathogenic agents such as viruses or parasites which fragment is preferably a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.

REFERENCES:
patent: 5084441 (1992-01-01), Shaw et al.
Butini, et al.: Comparative analysis of HIV-specific . . . Z:J Cell. Boi.: Supp. 18B; J 306, 1994.
Deres, et al. :In vivo priming of virus-specific cytotoxic t lymphocytes . . . :Nature: vol. 342: pp. 561-564, 1989.
Culmann, et al.: An antigenic peptide of the HIV-1 NEF protein . . . :Eur. J. Immunol.: 19: pp. 2383-2386, 1989.
Haynes, et al. : Toward an understanding of the correlates . . . : Science: vol. 271: pp. 324-328, Jan. 1996.

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