Cytotoxic T lymphocyte activation assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 19, 435 29, 435 34, 436503, 436548, 436827, G12Q 144, G01N 33577

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active

051806622

ABSTRACT:
A method is provided for the quantitative study of cytotoxic T-lymphocyte activation by measuring secreted granule-associated BLT esterase activity after incubating the cytotoxic T-lymphocytes with activating stimuli. This method can be used to screen inhibiting (drugs) or activating agents (monoclonal antibodies) (at selected sub-optimal levels of activation of cytotoxic T-lymphocytes.

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Takayama et al. J. Immunol. Meth. 104: 183-190, 1987.
Takayama et al. J. Immunol. 138: 566-569, Jan. 15, 1987.
Takayama et al. J. Immunol. 139: 1014-1021, Aug. 15, 1987.
Redelman, et al. J. Immunol. 124: 870-878, 1980.
Takayama et al, "A Novel Cytotoxic T Lymphocyte Activation Assay", J. Imm. Methods 104, 183-190 (1987).
Takayama et al, "Antigen Receptor-Triggered Secretion of a Trypsin-type Esterase from Cytotoxic T Lymphocytes. . . ", J. Imm. 138, 566-569 (Jan. 15, 1987).
Takayama et al, "T Cell Antigen Receptor Triggered Exocytosis in Cytotoxic T Lymphocytes . . . ", J. Imm. 139, 1014-1021 (Aug. 15, 1987).
Redelman et al, "The Mechanism of Cell-Mediated Cytotoxicity", J. Imm. 124, 870-878 (Feb. 1980).

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