Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-11-08
1993-01-19
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 19, 435 29, 435 34, 436503, 436548, 436827, G12Q 144, G01N 33577
Patent
active
051806622
ABSTRACT:
A method is provided for the quantitative study of cytotoxic T-lymphocyte activation by measuring secreted granule-associated BLT esterase activity after incubating the cytotoxic T-lymphocytes with activating stimuli. This method can be used to screen inhibiting (drugs) or activating agents (monoclonal antibodies) (at selected sub-optimal levels of activation of cytotoxic T-lymphocytes.
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Redelman, et al. J. Immunol. 124: 870-878, 1980.
Takayama et al, "A Novel Cytotoxic T Lymphocyte Activation Assay", J. Imm. Methods 104, 183-190 (1987).
Takayama et al, "Antigen Receptor-Triggered Secretion of a Trypsin-type Esterase from Cytotoxic T Lymphocytes. . . ", J. Imm. 138, 566-569 (Jan. 15, 1987).
Takayama et al, "T Cell Antigen Receptor Triggered Exocytosis in Cytotoxic T Lymphocytes . . . ", J. Imm. 139, 1014-1021 (Aug. 15, 1987).
Redelman et al, "The Mechanism of Cell-Mediated Cytotoxicity", J. Imm. 124, 870-878 (Feb. 1980).
Saunders David
The United States of America as represented by the Department of
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