Cytotoxic T lymphocte serine esterase and method for stimulation

Details Cytotoxic T lymphocte serine esterase and method for stimulation Cytotoxic T lymphocte serine esterase and method for stimulation

1988-08-22

1991-05-21

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435213, 435226, 424 858, 424 8591, 530387, 530388, C12N 916, C12N 948, A61K 39395, A61K 3944

Patent

active

050174894

ABSTRACT:
Antibodies, nucleic acid sequences, and methods for inhibition of lysis for a novel serine esterase produced by both murine and human cytotoxic T lymphocytes. The serine esterase has an apparent molecular weight of approximately 28,000-31,000, as determined by SDS gel electrophoresis under reducing conditions, and trypsin-like activity. Inhibition of the esterase correlates with inhibition of the cells' cytolytic activity. Specific inhibition of the serine esterase is useful as a method for immunosuppression as well as for the inhibition of cytolytic activity of T lymphocytes, both in vivo and in vitro. The genes encoding the murine and human serine esterase are homologous.

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