Cytotoxic protein hybrid and process for the preparation thereof

Details Cytotoxic protein hybrid and process for the preparation thereof Cytotoxic protein hybrid and process for the preparation thereof

1981-12-16

1982-12-14

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424 88, A61K 3944, C07G 700

Patent

active

043637582

ABSTRACT:
A cytotoxic protein hybrid obtained by covalently bonding an immunoglobulin or its fragment, which is capable of linking selectively with an antigen possessed by a cell to be destroyed, to a protein, which is obtained from Phytolacca americana and has an activity to terminate protein synthesis. This protein hybrid displays remarkable cytotoxicity against target cells.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4093607 (1978-06-01), Sela et a.
patent: 4315851 (1982-02-01), Yoshikumi et al.
Archives of Biochemistry & Biophysics, 169, pp. 522-528, (1975), Irvin.
J. Natl. Cancer Inst., vol. 61, pp. 657-676, Ghose et al. (1978).
Biochemical Biophysical Res. Comm., vol. 90, pp. 320-360, (1979), Masuho et al.

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