Cytotoxic protein from Trichosanthes kirilowii

Details Cytotoxic protein from Trichosanthes kirilowii Cytotoxic protein from Trichosanthes kirilowii

1989-11-13

1992-09-22

Nucker, Christine

Drug, bio-affecting and body treating compositions

Lymphokine

530370, 530379, 5303917, 530405, 530408, 530409, 514 12, 514 21, A61K 3944, C07K 1510, C07K 1702

Patent

active

051495287

ABSTRACT:
Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used within a method for inhibiting protein synthesis in selected cells.

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