Cytotoxic protein from the yeast Pichia inositovora

Details Cytotoxic protein from the yeast Pichia inositovora Cytotoxic protein from the yeast Pichia inositovora

1991-07-22

1993-06-01

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

530371, C12P 102, C07K 1300

Patent

active

052158985

ABSTRACT:
A novel cytotoxic protein is described possessing antifungal activity and which may be used for the treatment of fungal infections, or the prevention or control of fungal growth, as well as being potentially valuable as a biopesticide such as an insecticide, nematicide, or herbicide. The protein is produced by culture of Pichia inositovora strain NRRL Y-18709, and may be subsequently recovered from the culture medium and purified.

REFERENCES:
patent: 4418150 (1983-11-01), Gunge
G. T. Hayman & P. L. Bolen, Linear DNA Plasmids of Pichia inositovora Are Associated with a Novel Killer Toxin Activity, Curr. Genet. 19:389-393 (1991).
G. T. Hayman & P. L. Bolen, Linear DNA Plasmids of Pinchia inositovora Are Associated with a Novel Killer Toxin Activity, 15th Int. Conf. on Yeast Genetics & Molecular Biology, The Netherlands, Abstr. S548 (1990).
J. M. Ligon et al., Physical and Biological Characterization of Linear DNA Plasmids of the Yeast Pinchia inositovora, Plasmid 21: 185-194 (1989).

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