Cytotoxic products formed by covalent bonding of the A chain of

Details Cytotoxic products formed by covalent bonding of the A chain of Cytotoxic products formed by covalent bonding of the A chain of

1979-09-27

1982-07-20

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 85, A61K 3944, C07G 700

Patent

active

043405355

ABSTRACT:
Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognizing a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the A chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.

REFERENCES:
patent: 4046722 (1977-09-01), Rowlands
patent: 4093607 (1978-06-01), Sela et al.
Annals of the N.Y. Acad. of Sciences, 277, 690-699, (1976), Moolten et al.

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