Cytotoxic nucleoside-corticosteroid phosphodiesters

Details Cytotoxic nucleoside-corticosteroid phosphodiesters Cytotoxic nucleoside-corticosteroid phosphodiesters

1979-08-06

1981-08-11

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugate includes potentiator; or composition comprising...

536 5, 536 6, 536 7, C07J 1700

Patent

active

042833949

ABSTRACT:
Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: ##STR1## wherein: steroid is the residue formed by removal of a hydroxyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position;

REFERENCES:
patent: 3325474 (1967-06-01), Sarett et al.
patent: 3904599 (1975-09-01), Stache et al.
patent: 4083969 (1978-04-01), Inoue et al.

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