Cytotoxic metabolites from Myriapora truncata

Details Cytotoxic metabolites from Myriapora truncata Cytotoxic metabolites from Myriapora truncata

1994-02-18

1996-05-07

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514475, 549414, A61K 3135, A61K 31335, C07D30910, C07D30332

Patent

active

055147089

ABSTRACT:
The present invention is based upon the discovery that the methanol extract of the bryozoan Myriapora truncata showed potent cytotoxicity against L1210 murine leukemia cells (99% inhibition at 50 .mu.g/mL). Fractionation and purification of active components from this extract, guided by a cytotoxicity assay, resulted in the isolation of a novel, highly cytotoxic polyketide-derived metabolite MT-332 (Compound 3) and its equilibrium isomer (Compound 4), along with two less active compounds, MT-381 (Compound 1) and MT-381-B (Compound 2). The equilibrium mixture of Compounds 3 and 4 showed 88% inhibition at 0.2 .mu.g/mL against L1210 cells. ##STR1##

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