Cytotoxic liponucleotide analogs

Details Cytotoxic liponucleotide analogs Cytotoxic liponucleotide analogs

1980-01-18

1981-09-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 27, 536 28, 536 29, A61K 3170, C07H 1910, C07H 1920

Patent

active

042910242

ABSTRACT:
Nucleotides of nucleosides or bases having known cytotoxic activity are reacted to form corresponding cytotoxic liponucleotide analogs by phosphorylation of molecular species of phosphatidic acids. The resulting cytotoxic liponucleotide analogs exhibit an enhanced therapeutic index and broader spectrum of antitumor activity as compared to the parent nucleoside or base compounds, apparently due to an improved selective uptake thereof by metabolizing tumor cells, and are thus useful cytotoxic, antiviral and antineoplastic agents.

REFERENCES:
patent: 3787392 (1974-01-01), Bergmeyer
patent: 3872083 (1975-03-01), Okutsu et al.
Srivastava, S., Diss. Abstr. Int. B 36, 4502, (1976).
Poorthuis, B., and Hostetler, K., Biochem. et Biophys. Acta, vol. 431, pp. 408-415, (1976).
Hostetler, K., et al., Biochem. et. Biophys. Acta, vol. 380, pp. 382-389, (1975).

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