Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-06-06
1998-03-17
Leary, Louise
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 34, 435 4, 435 18, 435 72, 435 721, 4352402, 4352401, 436 63, 436 74, 436501, 436171, 436827, 436828, 422 8203, 422 55, 250281, 356302, C12Q 137, C12Q 104, G01N 33567, C12N 500
Patent
active
057285403
ABSTRACT:
Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.
REFERENCES:
patent: 4311686 (1982-01-01), Angers et al.
patent: 4346074 (1982-08-01), Gilmour et al.
patent: 4388298 (1983-06-01), Nazerian et al.
patent: 4396600 (1983-08-01), Messineo et al.
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4647773 (1987-03-01), Gallo et al.
patent: 4708818 (1987-11-01), Montagnier et al.
patent: 4900553 (1990-02-01), Silver et al.
patent: 5158976 (1992-10-01), Rosenburg et al.
patent: 5219837 (1993-06-01), Cohen et al.
patent: 5225352 (1993-07-01), Zanetta et al.
patent: 5585262 (1996-12-01), Perron et al.
ATCC Catalogue of Cell Lines and Hybridomas, Sixth Edition, 1988, pp. 165 and 344-355.
C.R.M. Bangham et al., "PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-1", Science, vol. 246, Nov. 10, 1989, pp. 821-824.
R. Baccala et al., "Genomically Imposed and Somatically Modified Human Thymocyte vb Gene Repertoires", Proc. Natl. Acad. Sci., vol. 88, pp. 2908, 1991.
T. Bergstrom et al., "Isolation of Herpes Virus Type 1 During First Attack of Multiple Sclerosis.", Annales Neurology, vol. 26, pp. 283-285, (1989).
Bjare, "Serum-Free Cell Culture", Pharmac. Ther., vol. 53, 1992, pp. 355-374.
C. Bosgiraud et al., "Ultrastructural Study on Visna Virus in Sheep Plexus Choroid Cells", Biological Abstracts, vol. 83, No. 7, 1987.
D. Ross Boswell et al., "Sequence comparison and alignment: the measurement and interpretation of sequence similarity", Computational Molecular Biology, Sources and Methods for Sequence Analysis, pp. 161-178.
Chomczynski et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", Anal. Biochem., 1987, vol. 162, pp. 156-159.
Cook et al., "Multiple Sclerosis and Distemper in Iceland 1966-1978", Acta Neurol. Scandinav. 61, 1980, pp. 244-251.
S. Dhib-Jalbut et al., "Measles Virus Polypeptide-Specific Antibody Profile in Multiple Sclerosis", Neurology, vol. 40, pp. 430-435, (1990).
Dunn et al., "A Novel Method to Map Transcripts: Evidence for Homology Between and Adenovirus mRNA and Discrete Multiple Regions of the Viral Genome", Cell, vol. 12, Sep. 1977, pp. 23-36.
Elian et al., "Multiple Sclerosis Among United Kingdom-Born Children of Immigrants from the Indian Subcontinent, Africa and the West Indies", J Neurol Neurosurg Psychiat, 1990; 53, pp. 906-911.
E. J. Field, "Immunological Treatment for Multiple Sclerosis", The Lancet, Jun. 3, 1989, p. 1272.
Frohman et al., "Rapid Production of Full-Length cDNAs from Rare Transcripts: Amplification Using a Single Gene-Specific Oligonucleotide Primer", Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 8998-9002.
Medline Abstract of FU et al., "Rabies virus nucleoprotein expressed in and purified from insect cells is efficacious as a vaccine," Proc Natl Acad Sci USA 88: 2001-05 (1991).
M. B. Gardner et al., "Congenital Transmission of Murine Leukaemia Virus from Wild Mice Prone to Development of Lymphoma and Paralysis", J. Natl. Cancer Inst., vol. 62, pp. 63-69, (1979).
M. B. Gardner, "Genetic resistance to a Retroviral Neurologic Disease in Wild Mice, in Retrovirus Infectious of the Nervous System", Oldstone M.B.A. and Koprowsky H. Eds. Current Topice in Microbiology and Immunology, No. 160, pp. 3-10, (Springer-Verlag, Berlin, 1990).
A. Gessain et al., "Intrathecal Synthesis of Antibodies to Human T Lymphotropic Virus Type I and the Presence of IgG Oligoclonal Bands in the Cerebrospinal Fluid of Patients with Endemic Tropical Spastic Paraparesis", The Journal of Infectious Diseases, vol. 157, No. 6, Jun. 1988, pp. 1226-1234.
A. Gessain et al., "Antibodies to Human T-Lymphotrophic Virus type-I in Patients with Tropical Spastic Paraparesis", Lancet, vol. 2, pp. 407-410, (1985).
F. Gonzalez-Scarano et al., "Sequence Similarities Between Human Immunodeficiency Virus gp41 and Paramyxovirus Fusion Proteins.", AIDS Res. Hum. Retrov., vol. 3, pp. 245-252, (1987).
S.J. Greenberg et al., "Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification", Proc. Natl. Acad. Sci. USA, vol. 86, Apr. 1989, pp. 2878-2882.
S. Haahr et al., "A Putative New Retrovirus Associated with Multiple Sclerosis and the Possible Involvement of Epstein-Barr Virus in this Disease", NY Acad. Science, vol. 724, pp. 148-156, 1994.
S. Haahr et al., "Is Multiple Sclerosis Caused by a Dual Infection with Retrovirus and Epstein-Barr Virus?", Neuroepidemiology, vol. 11, pp. 299-303, (1992).
S. Haahr et al., "Just Another Dubious Virus in Cells from a Patient with Multiple Sclerosis?", The Lancet, vol. 337, Apr. 6, 1991, pp. 863-864.
A. T. Haase, "Pathogenesis of Lentivirus Infections", Nature, vol. 322, Jul. 10, 1986, pp. 130-136.
S.L. Hauser et al., "Analysis of Human T-lymphotropic virus sequences in multiple sclerosis tissue", Nature, vol. 322, Jul. 10, 1986, pp. 176-178.
Hirayama et al., "Serum-Mediated Oligodendrocyte Cytotoxicity in Multiple Sclerosis Patients and Controls", Neurology 1986, vol. 36, pp. 276-278.
Hoffman et al., "Handbook of Clinical Neurology, 12; Viral Diseases", R.R. McKendall, ed., Elseveier Science Publishing, Amsterdam, 1989, pp. 453-466.
Huang, "Defective Interfering Viruses", Fundamental Virology, Fields et al., eds., 1986, pp. 101-117.
A. W. Hugin et al., "A Virus-Encoded Superantigen in a Retrovirus-Induced Immunodeficiency Syndrome of Mice", Science, vol. 252, pp. 424-427, (1991).
James, "Multiple Sclerosis or Blood-Brain Barrier Disease", The Lancet, Jan. 7, 1989, p. 46.
Medline abstract of Jarrett et al., "Studies on vaccination against papillomaviruses: a comparison of purified virus, tumour extract and transformed cells in prophylactic vaccination," Vet Rec 126: 449-52 (1990).
D. Johnson et al., "Quantitation of the Myelin-Associated Glycoprotein in Human Nervous Tissue from Controls and Multiple Sclerosis Patients", Journal of Neurochemistry, vol. 46, No. 4, 1986, pp. 1086-1093.
Johnson, "Viral Aspects of Multiple Sclerosis", Handbook of Clinical Neurology, vol. 3(47):Demyelinating Diseases, 1985, pp. 319-336.
R.T. Johnson, "Nononcogenic Retrovirus Infections as Models for Chronic and Relapsing Human Diseases: Introduction", Reviews of Infectious Diseases, vol. 7, No. 1, Jan.-Feb. 1985, pp. 66-67.
Karpas et al., "Lack of evidence for involvement of known human retroviruses in multiple sclerosis", Nature, vol. 322, 10 Jul. 1986, pp. 177-178.
H. Koprowski et al., "Multiple sclerosis and human T-cell lymphotropic retroviruses", Nature, vol. 318, Nov. 14, 1985, pp. 154-160.
G. La Mantia et al., "Identification of New Human Repetitive Sequences: Characterization of the Corresponding cDNAs and their Expression in Embryonal Carcinoma Cells", Nucleic Acids Research, vol. 17, No. 15, 5913-5922, (1989).
G. La Mantia et al., "Identification and Characterization of Novel Human Endogenous Retroviral Sequences Prefentially Expressed in Undifferentiated Embryonal Carcinoma Cells", Nucleic Acids Res., 1991, vol. 19, No. 7, pp. 1513-1520.
H. Lassmann et al., "Chronic Relapsing Experimental Allergic Encephalomyelitis-Clinicopathological Comparison with Multiple Sclerosis", Arch Neurol, vol. 36, Aug. 1979, pp. 490-497.
Medline abstract of LEAO, "Tuberculosis: new strategies for the development of diagnostic tests and vaccines," Braz J Med Biol Res 26: 827-33 (1993).
Y.S. Lie et al., Journal of Virology, vol. 68, No. 12, Dec. 1994, pp. 7840-7849, "Chinese hamster ovary cells contain transcriptionally active full length type C provirises".
Linial et al., "Retroviral RNA Packaging: Sequence Requirements and Implications", in Current Topics in Microbiology and Immunobiology. Retroviruses, Strategies of Replication, Swanstrom et al., eds., vol. 157, 1990, pp. 125-152.
R. Lisak et al., "In Vitro Cell-Mediated Immunity of Cerebrospinal-Fluid Lym
Dobransky Tomas
Mandrand Bernard
Perron Herve
Rieger Fran.cedilla.ois
Bio Merieux
Leary Louise
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