Cytotoxic enhancement of TNF with copper

Details Cytotoxic enhancement of TNF with copper Cytotoxic enhancement of TNF with copper

1994-06-07

1997-05-27

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Lymphokine

424604, 4241381, 4241431, 4241781, 4241791, 4241811, A61K 3819, A61K 3334, A61K 3900

Patent

active

056329822

ABSTRACT:
Copper chelates serve as cytotoxic agents in conjunction with a surface membrane protein receptor internalizing agent, particularly TNF, which has independent cytotoxic activity, for use against target cells. By employing concentrations of the two agents, where the agents have substantially reduced adverse side effects, the combination is shown to have effective cytotoxic activity.

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