Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-08-06
1992-02-11
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530345, 530399, 530342, 530408, 530409, 530410, A61K 3736, A61K 3702, C07K 1300
Patent
active
050876163
ABSTRACT:
A therapeutic composition comprising a chemical conjugatge including a first moiety, other than an immunoglobulin or fragment thereof, such as epidermal growth factor, which preferentially binds to a tumor cell, and is internalized by the cell, and a second moiety linked to the first moiety, and comprising a biodegradable polymeric carrier, such as polyglutamic acid, to which one or more cytotoxic molecules, for instance, daunomycin, are attached. The degradation of the carrier by intracellular enzymes releases a cytotoxic agent, resulting in selective destruction of the tumor cells.
REFERENCES:
patent: 3917824 (1975-11-01), Camble et al.
patent: 4485093 (1984-11-01), Runge
patent: 4528186 (1985-07-01), Nishimura et al.
patent: 4545985 (1985-10-01), Pastan et al.
Thorpe, Philip, Ph.D., Tumor Imaging and Drug Targeting, British Med. Bul. (1984), vol. 40, No. 3, pp. 233-239.
Hurwitz et al., The Covalent Binding of Daunomycin and Adriamycin to Antibodies, with Retention of Both Drug and Antibody Activities; Cancer Res. 35, 1175-1181, May 1975.
Kato et al., Antitumor Activity of 1--D-Arabinofuranosylcytosine Conjugated with Polyglutamic Acid and Its Derivative, Cancer Res. 44, 25-30, 1984.
Masquelier et al., Amino Acid and Dipeptide Derivatives of Daunorubicin, J. Med. Chem, 1980, 23, 1166-1177.
O'Keefe et al., Characterization of a Transferrin-Diphtheria Toxin Conjugate, The Journal of Biological Chem., 1985, vol. 260, No. 2, 932-937.
Bacha et al., Thyrotropin-Releasing Hormone-Diphtheria Toxin-Related Polypeptide Conjugates, The Journal of Biological Chem., vol. 258, No. 3, 1565-1570, 1983.
Murphy et al., Genetic Construction, Expression, and Melanoma-Selective Cytotoxicity of a Diphtheria Toxin-Related .alpha.-Melanocyte-Stimulating Hormone Fusion Protein, Proc. Natl. Acad. Sci., vol. 83, 8258-8262, 1986.
Pastan et al., Immunotoxins, Cell, vol. 47, 641-648, 186; Potman et al., Optimization of Macromolecular Prodrugs of the Antitumor Antibiotic Adriamycin, Journal of Controlled Re. 2, (1985), 205-213.
Kato et al., A Novel Method of Conjugation of Daunomycin with Antibody with a Poly-L-Glutamic Acid Derivative as Intermediate Drug Carrier, J. Med. Chem., 1984, 27, 1602-1607.
Shimiazu et al., A Cytotoxic Epidermal Growth Factor Cross-Linked to Diphtheria Toxin A-Fragment, vol. 118, No. 2, 1980.
Cawley et al., Epidermal Growth Factor-Toxin A Chain Conjugates: EGF-Ricin A is a Potent Toxin While EGF-Diphtheria Fragment A is Nontoxic, Cell, vol. 22, 563-570, 1980.
Simpson et al., Killing of Cultured Hepatocytes by Conjugates of Asialofetuin and EGF Linked to the A Chains Ricin or Diphtheria Toxin, Cell, vol. m29, 469-473, 1982.
Bichon Daniel
Myers Andre E.
Battelle (Memorial Institute)
Moezie F. T.
LandOfFree
Cytotoxic drug conjugates and their delivery to tumor cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytotoxic drug conjugates and their delivery to tumor cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytotoxic drug conjugates and their delivery to tumor cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-781981