Cytotoxic diphtheria toxin fragments

Details Cytotoxic diphtheria toxin fragments Cytotoxic diphtheria toxin fragments

1991-11-22

1998-10-27

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530402, 530407, C07K 112, C07K 1434

Patent

active

058279342

ABSTRACT:
This invention relates to a modified diphtheria toxin (DT) and method of preparing the same in which two carboxy-terminal truncated forms of DT are prepared by specific chemical proteolysis generating two new proteins HA51DT and HA48DT which can be chemically linked to a cell specific binding moiety to produce potent cytotoxins. This invention further relates to carboxy terminal peptides formed in accordance with said proteolysis generating three peptides HA11DT, HA7DT and HA3DT.

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