Cytotoxic depsipeptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C435S071300, C514S009100, C530S323000, C530S331000, C530S333000, C530S825000

Reexamination Certificate

active

07446094

ABSTRACT:
Compounds of general formula (I) wherein R1, R2, R3are as defined and R4groups are each independently selected from NR2, O and S; are of use in treatment of cancers.

REFERENCES:
patent: 11-180997 (1999-07-01), None
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Kanoh et al., “Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251”, J. Antibiot., 58 (4), 2005, pp. 289-292.
Knight et al., “Synthesis of the Tris-oxazole Ring System of Ulapualides”, Synlett Letters, Jan. 1990, pp. 36-37.
Liu et al., “Studies Directed Toward the Total Synthesis of Kabiramide C: Asymmetric Synthesis of the C7-C19 Fragment”, Tetrahedron Letters, 39, 1998, pp. 6143-6146.
Panel et al., Studies Directed Toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C8-C25 Tris-Oxazole Fragment, J. Org. Chem., 61, 1996, pp. 6496-6497.
G. Pattenden, “Synthesis Studies with Natural Oxazoles and Thiazoles”, J. Heterocyclic Chem., 29, 1992, pp. 607-618.
Wipf et al., “Total Synthesis of (-)-Thiangazole and Structurally Related Polyazoles”, J. Org. Chem., 60, 1995, pp. 7224-7229.
Wipf et al., “A New Synthesis of Highly Funtionalized Oxazoles”, J. Org. Chem., 58, 1993, pp. 3604-3606.

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