Cytotoxic compounds

Details Cytotoxic compounds Cytotoxic compounds

1994-02-03

1995-09-12

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514529, 514572, 549357, 560118, 560119, 560126, 562498, 562500, 562501, 562508, A61K 31335, C07D30900, C07C 6974, C07C 6200

Patent

active

054496845

ABSTRACT:
Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: ##STR1## in which R.sup.1 is H or lower alkyl; R.sup.2 is OH or CH.sub.3 ; R.sup.3 is OH or CH.sup.3, and R.sup.4 H or MPTA. The compounds have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.

REFERENCES:
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patent: 5183924 (1993-02-01), Festal et al.
Manes et al., Tetrahedron Letters, vol. 25, No. 9, pp. 931-934 (1984).
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Capon et al., Tetrahedron, vol. 41, No. 16, pp. 3391-3404 (1985).
Albericci et al., Tetrahedron Letters, No. 29, pp. 2687-2690 (1979).
Tanaka et al., J. Org. Chem., 58, 2999-3002 (1993).
Kashman et al., Tetrahedron Lett., 1707 (1979).

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