Cytotoxic compositions of transferrin coupled to vinca alkaloids

Details Cytotoxic compositions of transferrin coupled to vinca alkaloids Cytotoxic compositions of transferrin coupled to vinca alkaloids

1984-02-21

1985-06-11

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260121, C07G 700, C07G 704

Patent

active

045227500

ABSTRACT:
There is provided by this invention cell-targeting cytotoxic compositions comprising transferrin covalently coupled to vinca alkaloid.

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patent: 4434156 (1984-02-01), Trowbridge
Merck Index, 9th Ed. (1976), pp. 30, 896 and 1230.
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Basala, M. and Raso, V., Federation Proceedings, vol. 42, No. 3, Abstract 2289, p. 683 (1983).
Hopkins, C. R. and Trowbridge, I. S., J. Cell Biol., 97, 508-521 (1983).
Gatter, K. C., Brown, G., Strowbridge, I. S., Woolston, R-E and Mason, D. Y., J. Clin. Pathol., 36, 539-545 (1983).
MacGillivray, R. T. A., Mendex, E., Shewale, J. G., Sinha, S. K., Lineback-Zins, J. and Brew, K., J. Biol. Chem., 258, 3543-3553 (1983).
Johnson, J. R., Ford, C. H. J., Newman, C. E., Woodhouse, C. S., Rowland, G. F. and Simmonds, R. G. Br. J. Cancer, 44, 472-475 (1981).

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