Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1990-08-28
1992-04-21
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530402, C07K 500, C07K 700, A61K 3700, A01N 5508
Patent
active
051069482
ABSTRACT:
A method is provided for inhibiting growth of cancer cells comprising contacting said cells with an effective growth-inhibiting amount of a compound of the formula (II): ##STR1## or a physiologically acceptable salt thereof, wherein A.sup.1 and A.sup.2 are individually L-amino acid residues selected from the group consisting of Ala, Pro, Gly, Glu, Leu, Lys, Phe, Ser, Val, Ile, Arg, Tyr, Thr, Asp, Asn and Gly; R.sup.1 is C.sub.1 -C.sub.6 (alkyl) which is unsubstituted or is substituted with an aromatic substituent or one or more in-chain bivalent groups selected from the group consisting of --O--, --CO--, --S--, --NH--, --CONH--, CH.dbd.CH--, and --SO.sub.2 --; Y.sup.1 and Y.sup.2 are each H, or taken together from a moiety derived from a dihydroxy compound, and R.sup.1 is H or an N-terminal protecting group.
REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4537773 (1985-08-01), Shenvi
Peptide Hormones, Parsons, Ed., "Characteristics of the Amino Acid as Components of a Peptide . . . ", pp. 1-6 (1976).
D. H. Kinder et al., J. Med. Chem., 28, (1985).
B. Goz et al., Biochem. Pharmacol., 35, 3587 (1986).
D. S. Matteson et al., J. Amer. Chem. Soc., 103, 5241 (1981).
C. A. Kettner and A. B. Shenvi, J. Biol. Chem., 259, 15106 (1984).
Ames Matthew M.
Kinder David H.
Kraus E. J.
Lee Lester L.
Mao Foundation for Medical Education and Research
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