Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1991-10-25
1993-03-30
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556141, 556142, 556427, C07F 702, C07F 1506
Patent
active
051985608
ABSTRACT:
The present invention relates to a novel and efficient process for the preparation of 8-hydroxybicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring system. The present invention also provides a method for treating mammalian malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound of the present invention.
REFERENCES:
J. Am. Chem. Soc., 1987, 109:3461 and 3462.
J. Am. Chem. Soc., 1987, 109:3464 and 3466.
Kende, et al., Tet. Lett. 1988, 29:4217-4220.
Magnus, et al., J. Am. Chem. Soc., 1988, 110:1626-1628.
Magnus, et al., J. Am. Chem. Soc., 1988, 110:6921-6923.
Tomioka, et al., Tet. Lett., 1989, 30:851-854.
Magnus, et al., Tet. Lett., 1989, 30:3637-3640.
Danishefsky, et al., J. Am. Chem. Soc., 1988, 110:6890-6891.
J. Org. Chem., 1989, 54:2781-2783.
J. Am. Chem. Soc., 1989, 111:7638-7641.
Magnus, et al., J. Org. Chem., 1990, 55(6):1709-1711.
Danishefsky, et al., J. Am. Chem. Soc., 1990, 112:3253-3255.
Kadow John F.
Wittman Mark D.
Bristol--Myers Squibb Company
Dees Jos,e G.
Nazario Porfirio
Yang Mollie M.
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