Cytotoxic bicyclo [7.3.1.]tridec-4-ene-2,6-diyne compounds and p

Details Cytotoxic bicyclo [7.3.1.]tridec-4-ene-2,6-diyne compounds and p Cytotoxic bicyclo [7.3.1.]tridec-4-ene-2,6-diyne compounds and p

1992-12-18

1994-06-07

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514512, 514513, 544354, 544355, 546263, 546265, 549545, 549553, 549562, 558260, 558267, 558276, 560 32, 560115, 560162, 560256, A61K 3121, C07D24136, C07D30300

Patent

active

053189892

ABSTRACT:
The present invention relates to a novel and efficient process for the preparation of 8-hydroxybicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring system. The present invention also provides a method for treating mammalian malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound of the present invention.

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