Cytotoxic antibody conjugates of hydrazide derivatized methotrex

Details Cytotoxic antibody conjugates of hydrazide derivatized methotrex Cytotoxic antibody conjugates of hydrazide derivatized methotrex

1988-08-08

1991-07-02

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530389, 530390, 530391, 424 8591, C07K 1706, A61K 3944

Patent

active

050286978

ABSTRACT:
Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.

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Shen et al., Biochem. Biophys. Res. Comm. 102, 1048-54 (1981).
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Bumol et al., J. Cell Biochem., Supp. 9A, Abstract 0124 (1985).
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Lopes et al., Clinical Immunology (Proc. First IUIS Conference, Jul. 6-11, 1986).
Ghose et al., CRC Critical Rev. in Therapeutic Drug Carrier Systems 3, 263-359 (1987).

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