Cytotoxic annonaceous acetogenins from Annona muricata

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S320000, C549S323000

Reexamination Certificate

active

10005324

ABSTRACT:
Acetogenins isolated fromAnnona muricataof the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective cytotoxicity for various human tumor cell lines.

REFERENCES:
patent: 5955497 (1999-09-01), McLaughlin et al.
patent: 6242483 (2001-06-01), McLaughline et al.
Grever et al, Seminars in Oncology, vol. 19 No. 6 (Dec. 1992), The National Cance Institute: Cancer Drug Discovery and Development Program, pp. 622-628.
Alali, F.Q. et al.; Annonaceous Acetogenins: Recent Progress; Invited Review; J. Nat. Prod., 1999, vol. 62, pp. 504-540.
Li, Chao Ming et al.; Three New Bioactive Annonaceous Acetogeninins fromAnnona muricata; Chinese Chemical Letters, 1994, vol. 5, No. 9, pp. 747-750.
Rieser, Matthew J. et al.; Muricatetrocins A and B and Gigantetrocin B: Three New Cytotoxic Monotetrahydrofuran-Ring Acetogenins fromAnnona muricata; Helvetica Chimica Acta, 1993, vol. 76, pp. 2433-2444.
Liaw, Chih-Chuang et al.; New Annonaceous Acetogenins fromRollinia mucosa; J. Nat. Prod., 1999, vol. 62, pp. 1613-1617.
Chang, Fang-Rong et al.; Bioactive acetogenins from the seeds ofAnnona atemoya; Phytochemistry, vol. 51, 1999, pp. 883-889.
Chen, Chung-Yi et al.; Aromin-A, an Annonaceous acetogenin fromAnnona cherimola; Phytochemistry, vol. 51, 1999, pp. 429-433.
Hoye, Thomas R. et al.; Stereostructural Studies on the 4-Hydroxylated Annonaceous Acetogenins: A Novel Use of Mosher Ester Data for DeterminingRelativeConfiguration [Between C(4) and C(36)]; Tetrahedron Letters, vol. 35, 1994, No. 46, pp. 8529-8532.
Chavez, Daniel et al.; Purpurediolin and Purpurenin, Two New Cytotoxic Adjacent Bis-tetrahydrofuran Annonaceous Acetogenins from the Seeds ofAnnona purpurea; J. Nat. Prod., 1998, vol. 61, pp. 580-584.
Gawronski, J. et al.; A Note on the Determination of Absolute Configuration of Acetogenins by Circular Dichroism; Polish J. Chem., 1999, vol. 73, pp. 241-243.
Fujimoto, Yoshinori et al.; Annonaceous Acetogenins from the Seeds ofAnnona squamosa, Non-adjacent Bis-tetrahydrofuranic Acetogenins; Chem. Pharm. Bull. vol. 42(6), 1994, pp. 1175-1184.
Miyoshi, Hideto et al.; Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I; Biochimica et Biophysica Acta, vol. 1365, 1998, pp. 443-452.

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