Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-04-18
2009-06-23
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S511000, C514S449000
Reexamination Certificate
active
07550609
ABSTRACT:
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
REFERENCES:
patent: 5399726 (1995-03-01), Holton et al.
patent: 5416064 (1995-05-01), Chari et al.
patent: 5475011 (1995-12-01), Ojima et al.
patent: 5475092 (1995-12-01), Chari et al.
patent: 5646176 (1997-07-01), Golik et al.
patent: 5811452 (1998-09-01), Ojima et al.
patent: 5824701 (1998-10-01), Greenwald et al.
patent: 6175023 (2001-01-01), Lui
patent: 6340701 (2002-01-01), Chari et al.
patent: 2123363 (1994-11-01), None
patent: 2264610 (1998-05-01), None
patent: 2362937 (2000-08-01), None
patent: 0624377 (1994-05-01), None
patent: 1033372 (2000-09-01), None
patent: WO 89/12624 (1989-12-01), None
patent: WO 97/44026 (1997-11-01), None
patent: WO 98/19705 (1998-05-01), None
patent: WO 98/52614 (1998-11-01), None
patent: 99/25729 (1999-05-01), None
patent: WO 00/50059 (2000-08-01), None
Taxanes in Cancer Treatment [online], [retrieved on Feb. 28, 2007]. Retrieved from the internet, URL<http://cancerweb.ncl.ac.uk/cancernet/600715.html>.Feb. 28, 2007.
GI50 Mean Graph for Compound 125973 [online], [retrieved on Feb. 21, 2007]. Retrieved from the internet, URL<http://dtp.nci.nih.gov/dtpstandard/servlet/MeanGraphSummary?testshortname=Cancer+Screen+09%2F2003+Data&searchtype=NSC&searchlist=125973>.
Shoemaker, Robert H., Nature Reviews, vol. 6, Oct. 2006, pp. 813-823.
No copy provided as applicant provided copies with the remarks of Jan. 22, 2008.
Golik et al., “Synthesis and Antitumor Evaluation of Paclitaxel Phosphonooxymethyl Ethers: A Novel Class of Water Soluble Paclitaxel Pro-Drugs”, Bioorganic & Medicinal Chemistry Letters, vol. 6 No. 15, pp. 1837-1842, 1996.
Huff, “HIV Protease: A Novel Chemotherapeutic Target for AIDS”, Journal of Medicinal Chemistry, vol. 34, No. 8, pp. 2305-2314, (1991).
Lala et al., “Role of Nitric Oxide in Tumor Progression: Lessons from Experimental Tumors”, Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Golub et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”, Science (1999), vol. 286, 531-537.
Ojima et al, “A Common Pharmacophore for Cytotoxic Natural Products that Stabilize Microtubules,”Proc. Natl. Acad. Sci., USA,96:4256-4261 (1999).
Michael L. Miller, et al. “Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodiesm”Bioorganic&Medicinal Chemistry Letters14, 4079-4082 (2004).
Erkan Baloglu, et al. “Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors,”Bioorganic&Medicinal Chemistry Letters14, 5885-5888 (2004).
Michael L. Miller, et al. “Synthesis of Taxoids with Improved Cytotoxicity and Solubility for Use in Tumor-Specific Delivery,”J. Med. Chem.,47, 4802-4805 (2004).
Huff, “HIV Protease: A Novel Chemotherapeutic Target for AIDS,”Journal of Medicinal Chemistry,vol. 34, No. 8, pp. 2305-2314 (1991).
Lala et al, “Role of nitric oxide in tumor progression: Lessons from experimental tumors,”Cancer and Metastasis Reviews(1998), 17(1), 91-106.
Golub et al, “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring,”Science(1999), vol. 286, 531-537.
Safavy et al, “Paclitaxel Derivatives for Targeted Therapy of Cancer: Toward the development of smart Taxanes,”Journal of Medicinal Chemistry,42, 4919-24 (1999).
Wang et al, Synthesis and Biological Activity of Advanced 2nd-Generation Taxoids, American Chemical Society Division of Medicinal Chemistry, Abstracts, 218th ACS National Meeting, Aug. 22-26, 1999 MEDI-038.
Ojima et al, “Syntheses and Structure-Activity Relationships of Taxoids Derived from 14 -Hydroxy-10-deacetylbaccatin III,”J. Med. Chem.,40:267-278 (1997).
Canadian Office Action issued Apr. 8, 2008, in CA 2,388,063.
Blättler Walter A.
Chari Ravi V. J.
Havlin Robert
Immunogen Inc.
Saeed Kamal A
Sughrue & Mion, PLLC
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