Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-05-15
2007-05-15
Anderson, Rebecca (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S374000, C546S196000, C549S510000, C549S511000
Reexamination Certificate
active
11203960
ABSTRACT:
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
REFERENCES:
patent: 5399726 (1995-03-01), Holton et al.
patent: 5416064 (1995-05-01), Chari et al.
patent: 5475011 (1995-12-01), Ojima et al.
patent: 5475092 (1995-12-01), Chari et al.
patent: 5646176 (1997-07-01), Golik et al.
patent: 5811452 (1998-09-01), Ojima et al.
patent: 5824701 (1998-10-01), Greenwald et al.
patent: 6175023 (2001-01-01), Liu
patent: 6340701 (2002-01-01), Chari et al.
patent: 0624377 (1994-05-01), None
patent: 1033372 (2000-09-01), None
patent: WO 89/12624 (1989-12-01), None
patent: WO 97/44026 (1997-11-01), None
patent: WO 98/19705 (1998-05-01), None
patent: WO 98/52614 (1998-11-01), None
patent: WO 00/50059 (2000-08-01), None
Golik et al., Bioorganic & Medicinal Chemistry Letters, vol. 6. No. 15, pp. 1837-1842, 1996.
Wang et al, Synthesis and Biological Activity of Advanced 2nd-Generation Taxoids, American Chemical Society Division of Medicinal Chemistry, Abstracts, 218th ACS National Meeting, Aug. 22-26 (1999) MEDI-038.
Ojima et al, “Syntheses and Structure-Activity Relationships of Taxoids Derived from 14 -Hydroxy-10-deacetylbaccatin III,”J. Med. Chem.,40:267-278 (1997).
Ojima et al, “A Common Pharmacophore for Cytotoxic Natural Products that Stabilize Microtubules,”Proc. Natl. Acad. Sci., USA,96:4256-4261 (1999).
Michael L. Miller, et al. “Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodiesm”Bioorganic&Medicinal Chemistry Letters14, 4079-4082 (2004).
Erkan Baloglu, et al. “Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors,”Bioorganic&Medicinal Chemistry Letters14, 5885-5888 (2004).
Michael L. Miller, et al. “Synthesis of Taxoids with Improved Cytotoxicity and Solubility for Use in Tumor-Specific Delivery,”J. Med. Chem.,47, 4802-4805 (2004).
Huff, “HIV Protease: A Novel Chemotherapeutic Target for AIDS,”Journal of Medicinal Chemistry,vol. 34, No. 8, pp. 2305-2314 (1991).
Lala et al, “Role of nitric oxide in tumor progression: Lessons from experimental tumors,”Cancer and Metastasis Reviews(1998), 17(1), 91-106.
Golub et al, “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring,”Science(1999), vol. 286, 531-537.
Safavy et al, “Paclitaxel Derivatives for Targeted Therapy of Cancer: Toward the development of smart Taxanes,”Journal of Medicinal Chemistry,42, 4919-24 (1999).
Huff, Joel, “HIV Protease: A Novel Chemotherapeutic Target for AIDS”, Journal of Medicinal Chemistry, vol. 34, No. 8, pp. 2305-2314, 1991.
Lala, Peeyush, et al., “Role of nitric oxide in tumor progression: Lessons from experimental tumors”, Cancer and Metastasis Reviews, 17(1), pp. 91-106, 1998.
Golub, T. R., et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”, Science, vol. 286, pp. 531-537, 1999.
Blättler Walter A.
Chari Ravi V. J.
Anderson Rebecca
ImmunoGen Inc.
Sughrue & Mion, PLLC
LandOfFree
Cytotoxic agents comprising taxanes and their therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytotoxic agents comprising taxanes and their therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytotoxic agents comprising taxanes and their therapeutic use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3723155