Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-12-06
2010-02-23
Andres, Janet L. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07667054
ABSTRACT:
The invention relates to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent.
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Miller et al, Synthesis of Potent Taxoids for Tumor-specific Delivery Using Monoclonal Antibodies, Bioorganic & Medicinal Chemistry Letters 14 (2004) 4079-4082.
Miller et al, Synthesis of Taxoids with Improved Cytotoxicity and Solubility for Use in Tumor-Specific Delivery, J. Med. Chem, 2004, 47, 4802-4805.
Ojima et al, Tumor-Specific Novel Taxoid-Monoclonal Antibody Conjugates, J. Med. Chem. 2002, 45, 5620-5623.
Baloglu Erkan
Chari Ravi V. J.
Commercon Alain
Miller Michael L.
Andres Janet L.
Aventis Pharma S.A.
Covington Raymond
Darkes Paul R.
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