Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing
Reexamination Certificate
2007-07-16
2010-12-14
Aeder, Sean E (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Reexamination Certificate
active
07851432
ABSTRACT:
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
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Chari Ravi V. J.
Widdison Wayne C.
Aeder Sean E
Immunogen Inc.
Sughrue & Mion, PLLC
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