Cytotoxic agents comprising new maytansinoids

Details Cytotoxic agents comprising new maytansinoids Cytotoxic agents comprising new maytansinoids

2007-10-02

2007-10-02

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S456000

Reexamination Certificate

active

10849136

ABSTRACT:
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

REFERENCES:
patent: 6573074 (2003-06-01), Fulston et al.
patent: 2003/0157669 (2003-08-01), Fulston
patent: 2004/0241174 (2004-12-01), Amphlett et al.

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