Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1992-07-13
1993-05-04
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Lymphokine
5142795, 540462, 5303888, 53038815, 5303917, 5303889, A61K 3900, A61K 31535, A61K 4900, A01N 5700
Patent
active
052080200
ABSTRACT:
A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a pharmaceutically acceptable carrier diluent or excipient. A method for killing selected cell populations comprising contacting a cell population or tissue suspected of containing cells from said selected cell population with a cytotoxic amount of a cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. An N-methyl-alanine-containing ester of maytansinol or an analogue of maytansinol, said N-methyl-alanine-containing ester comprising a linking group capable of linking an N-methyl-alanine-containing maytansinoid ester to a chemical moiety. N-methyl-cysteine-containing ester of maytansinol or an analogue of maytansinol.
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Blattler Walter A.
Chari Ravi J.
Goldmacher Victor S.
Lambert John M.
Hook Gregory
Immunogen Inc.
Waddell Frederick E.
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