Cytotoxic agents and methods of use

Details Cytotoxic agents and methods of use Cytotoxic agents and methods of use

2008-05-13

2008-05-13

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S200000, C548S125000, C548S126000, C548S400000, C548S452000, C514S449000

Reexamination Certificate

active

11077887

ABSTRACT:
Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly cell proliferative conditions, such as cancer and inflammatory conditions.

REFERENCES:
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5023252 (1991-06-01), Hseih
patent: WO 96/32105 (1996-10-01), None
patent: WO 96/32105 (1996-12-01), None
patent: WO 91/16322 (2001-10-01), None
patent: WO 02/47610 (2002-06-01), None
Seemuller, et al. “Proteasome from Thermoplasma acidophilum: A Threonine Protease”Science268:579-582 (1995).
Fenteany, et al. “Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin”Science268:726-731 (1995).
Shah et al. “Early clinical experience with the novel proteasome inhibitor PS-519”Br. J. Clin. Charmacol54:269-276 (2002).
Goldberg et al. “Not just research tools-proteasome inhibitors offer therapeutic promise”Nature Medicine8:338-340 (2002).
Kolb et al. “Catalytic Asymmetric Dihydroxylation”Chem. Rev.94:2483-2547 (1994).
Pink, et al. “PS-341 enhances chemotherapeutic effect in human xenograft models”Proc. Am. Assoc. Cancer Res.43:158 (2002).

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