Cytotoxic agents and methods of use

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C549S200000, C548S125000, C548S126000, C548S400000, C548S452000, C514S449000

Reexamination Certificate

active

07371875

ABSTRACT:
Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly cell proliferative conditions, such as cancer and inflammatory conditions.

REFERENCES:
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5023252 (1991-06-01), Hseih
patent: WO 96/32105 (1996-10-01), None
patent: WO 96/32105 (1996-12-01), None
patent: WO 91/16322 (2001-10-01), None
patent: WO 02/47610 (2002-06-01), None
Seemuller, et al. “Proteasome from Thermoplasma acidophilum: A Threonine Protease”Science268:579-582 (1995).
Fenteany, et al. “Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin”Science268:726-731 (1995).
Shah et al. “Early clinical experience with the novel proteasome inhibitor PS-519”Br. J. Clin. Charmacol54:269-276 (2002).
Goldberg et al. “Not just research tools-proteasome inhibitors offer therapeutic promise”Nature Medicine8:338-340 (2002).
Kolb et al. “Catalytic Asymmetric Dihydroxylation”Chem. Rev.94:2483-2547 (1994).
Pink, et al. “PS-341 enhances chemotherapeutic effect in human xenograft models”Proc. Am. Assoc. Cancer Res.43:158 (2002).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cytotoxic agents and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytotoxic agents and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytotoxic agents and methods of use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2753979

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.