Cytotoxic agents and methods of use

Details Cytotoxic agents and methods of use Cytotoxic agents and methods of use

2008-05-13

2008-05-13

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S200000, C548S125000, C548S126000, C548S400000, C548S452000, C514S449000

Reexamination Certificate

active

07371875

ABSTRACT:
Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly cell proliferative conditions, such as cancer and inflammatory conditions.

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Pink, et al. “PS-341 enhances chemotherapeutic effect in human xenograft models”Proc. Am. Assoc. Cancer Res.43:158 (2002).

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