Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-12
2008-12-23
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S250000, C514S280000, C544S233000, C544S238000, C544S342000
Reexamination Certificate
active
07468366
ABSTRACT:
The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
REFERENCES:
patent: 2915523 (1959-12-01), Moore et al.
patent: 2981731 (1961-04-01), Moore et al.
patent: 2985661 (1961-05-01), Hien et al.
patent: 3267107 (1966-08-01), Sallay
patent: 3272707 (1966-09-01), Tedeschi
patent: 3449330 (1969-06-01), Guglielmetti et al.
patent: 3538097 (1970-11-01), Lowe et al.
patent: 3542782 (1970-11-01), Houlihan et al.
patent: 3849561 (1974-11-01), Junzo et al.
patent: 3884911 (1975-05-01), Shimada et al.
patent: 3912740 (1975-10-01), Zee-Chang et al.
patent: 4749708 (1988-06-01), Maroko
patent: 4761417 (1988-08-01), Maroko
patent: 4761477 (1988-08-01), Ikekawa et al.
patent: 4925943 (1990-05-01), Kanmacher et al.
patent: 4938949 (1990-07-01), Borch et al.
patent: 4980344 (1990-12-01), Maroko
patent: 5106863 (1992-04-01), Hajos et al.
patent: 5126351 (1992-06-01), Luzzio et al.
patent: 5153178 (1992-10-01), Maroko
patent: 5190753 (1993-03-01), Behrens et al.
patent: 5244903 (1993-09-01), Wall et al.
patent: 5318976 (1994-06-01), Luzzi et al.
patent: 5639759 (1997-06-01), Magolda et al.
patent: 5646283 (1997-07-01), Suzuki et al.
patent: 5767142 (1998-06-01), La Voie et al.
patent: 5770617 (1998-06-01), LaVoie et al.
patent: 5807874 (1998-09-01), LaVoie et al.
patent: 5981541 (1999-11-01), LaVoie et al.
patent: 6140328 (2000-10-01), LaVoie et al.
patent: 6509344 (2003-01-01), Cushman et al.
patent: 6740650 (2004-05-01), LaVoie et al.
patent: 6964964 (2005-11-01), LaVoie et al.
patent: 6987109 (2006-01-01), LaVoie et al.
patent: 7049315 (2006-05-01), LaVoie et al.
patent: 7319105 (2008-01-01), LaVoie et al.
patent: 2004/0110760 (2004-06-01), LaVoie et al.
patent: 2005/0009824 (2005-01-01), LaVoie et al.
patent: 2005/0009826 (2005-01-01), LaVoie et al.
patent: 2005/0010046 (2005-01-01), LaVoie et al.
patent: 0108147 (1984-05-01), None
patent: 0496634 (1992-07-01), None
patent: 2108955 (1983-05-01), None
patent: 1530628 (1989-12-01), None
patent: WO-92/21661 (1992-12-01), None
patent: WO-96/36612 (1996-11-01), None
patent: WO-98/12181 (1998-03-01), None
patent: WO-98/31673 (1998-07-01), None
patent: WO-99/31067 (1999-06-01), None
patent: WO-00/21537 (2000-04-01), None
patent: WO 01/32631 (2001-05-01), None
patent: WO-03/041660 (2003-05-01), None
patent: WO-03/047505 (2003-06-01), None
patent: WO-2004/014918 (2004-02-01), None
Aguirre, J. M., et al., “Reaction of 1,2-diarylethylamides with ethyl polyphosphate(EPP): correlation of the von Braun, Ritter and Bischler-Napieralski reactions.”Chemical Abstracts,111(13), Abstract No. 115004, (1989), 646.
Akiyama, Shin-Ichi, et al., “Isolation and Genetic Characterization of Human KB Cell Lines Resistant to Multiple Drugs”,Somatic Cell and Molecular Genetics,11(2), (1985), 117-126.
Andoh, Toshiwo, et al., “Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I”,Prpceedings of the Natinal Academy of Sciences USA, 84(16), (1987), 5565-5569.
Andoh Toshiwo, et al., “Drug resistance mechanisms of topoisomerase I drugs”,Advances in Pharmacology, vol. 29B, DNA Topoisomerases: Topoisomerase- Targeting Drugs, (1994) 93-103.
Arumugam, N., et al., “Synthesis of 7,8-Benzophenanthridines”,Indian Journal of Chemistry, vol. 12, (1974), 664-667.
Badia, Dolores, et al., “Silicon-mediated isoquinoline synthesis: preparatio and stereochemical characterization of 4-hydroxy-3-phenylisoquinolines”,Chemical Abstrats,117913), Abstract No. 131034, (1992), 730.
Baezner, C., et al., “Uberfuhrung von o-nitro- und, o,p-dinitro-benzylchlorid in acridinderivate”,Berichte der Deutschen Chemischen Gesellschaft, 39, English Title—Conversion of o-nitro and o,p-dinitrobenzylchlroide into acridinic derivatives, (1906), 2438-2447.
Baezner, Carlo, “Uberfuhrung von o-nitro-und o, p-dinitro-benzylchlorid in acridinderivate”,Berichte der Deutschen Chemischen Gesellschaft, 37, English Title—Conversion of o-nitrobenzyl chloride and o,p-dinitrobenzyl chloride into acridine derivatives, (1904), 3077-3083.
Bhakuni, D. S., et al., “Protoberberine Alkaloids”,The Alkaloids, vol. 28, Chapter 2, Academic Press, Inc., (1986), 95-181.
Bjornsti, Mary-Ann, et al., “Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin”,Cancer Research,49, (1989), 6318-6323.
Bradsher, Charles K., et al., “alpha-Acyl-o-tolunitriles as intermediates in the preparation of 3-substitutes isoquinolines and 1-amino-2-benzopyrylium derivatives”,Chemical Abstracts, 89(21), Abstract No. 89: 179810b, (1978), 590.
Brossi, Arnold, “Benzo[c]phenanthridine Alkaloids”,The Alkaloids, Chemistry and Pharmacology, vol. XXV, Academic Press, Inc., (1985), 178-199.
Buu-Hoi, N. P., et al., “Carcinogenic Nitrogen Compounds. XV. Polysubstitute angular Benacridines and Benzophenarsazines”,Chemical Abstracts, 49(1), Abstract, col. 330, 10-Organic Chemistry, (1955), 329-330.
Buu-Hoi, N. G., et al., “The Chemistry of Carcinogenic Nitrogen Compounds. Part X. The Pfitzinger Reaction in the Synthesis of 1:2-Benzacridines”,Journal of the Chemical Society,Letchworth, GB, (1952), 279-281.
Buu-Hoi, N. G., “The chemistry of carinogenic nitrogen compounds. Part V. Angular hydroxybenzacridines and hydroxydibenzacridines”,Journal of the Chemical Society, Letchworth, GB, (1950), 2096-2099.
Carmichael, James, “Evaluation of the tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing”,Cancer Research, 47, (1987), 936-42.
Chen, Allan Y., “A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures”,Cancer Research, 53(6), (1993), 1332-1337.
Chen, Allan Y., et al., “DNA Minor Groove-Binding Ligands: A Different Class of Mammalian DNA Topoisomerase I Inhibitors”,Proceedings of the National Academy of Sciences of the United States of America, 90, (1993), 8131-8135.
Chen, Allan Y., et al., “DNA Topoisomerases: Essential Enzymes and Lethal TArgets”,Annu. Rev. Pharmacol. Toxicol., 34, (1994), 191-218.
Cherif, Abdallah, et al., “N-(5,5-Diacetoxypent-1-yl)doxorubicin: a new intensely potent doxorubicin analogue”,journal of Medicinal Chemistry, 35, (Aug. 21, 1992), 3208-3214.
Croisy-Delcey, M., et al., “Synthesis and carcinogenic activity of oxidized benzacridines: potential metabolites of the inactive isomer 12-methylbenz[a]acridine.”,journal of Medicinal Chemistry, 26, (1983), 303-306.
Cushman, Mark, et al., “Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride”,Journal of Medicinal Chemistry, 28, (1985), 1031-1036.
Cushman, Mark, et al., “Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors”,Journal of Medicinal Chemistry, 43(20), (2000), 3688-3698.
D'Arpa, Peter, et al., “Topoisomerase-targeting antitumor drugs”,Biochimica et Biophysica Acta, 989, (1989), 163-177.
Denizot, F., et al., “Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability”,Journal of Immunological Methods, 89, (1986), 271-277.
Denny, W.A., “Emerging DNA Topoisomerase Inhibitors as Anticancer Drugs”,Expert Opin. Emerg. Drugs,9 (1), (2004), 105-133.
Dominguez, Esther, et al., “Dehydrogenation reactions of 1-substituted-3-aryltetrahydroisoquinoline derivatives”,Chemical Abstracts, 101(11), Abstract No. 090742z, (1984), 624.
Dorof
LaVoie Edmond J.
Liu Leroy F.
Ray Abhijit
Ruchelman Alexander L.
Singh Sudhir K.
Balasubramanian Venkataraman
Rutgers The State University of New Jersey
Viksnins Harris & Padys PLLP
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