Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-06
1998-12-01
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 435 711, 435 712, 4352523, 435325, 4353201, C07K 14475
Patent
active
058440810
ABSTRACT:
A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.
REFERENCES:
Amemiya et al. "Cytostatin, A Novel Inhibitor Of Cell Adhesion To Components Of Extracellular Matrix Produced by Streptomyces sp. MJ654-NF4 I", Jnl. of Antibiotics, 47(5): 536-540 (May, 1994).
Amemiya et al. "Cytostatin, A Novel Inhibitor Of Cell Adhesion To Components Of Extracellular Matrix Produced by Streptomyces sp. MJ654-NF4 II", Jnl. of Antibiotics, 47(5): 541-544 (May, 1994).
Yamazaki et al. "Screening for Apoptosis Inducers in Microbial Products and Induction of Apoptosis by Cytostatin", Jnl. of Antibiotics, 48(10):1138-1140 (Oct. 1995).
Gentz Reiner
Ni Jian
Rosen Craig A.
Yu Guo-Liang
Benson Robert H.
Brookes A. Anders
Human Genome Sciences Inc.
Mertz Prema
Ulm John
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